Get FREE Price Alerts

Subscribe to our weekly cruise deals email and enjoy FREE price change alerts and updates for this cruise and others like it.

Email Address

Track this Cruise

We promise to protect your privacy and personal data. You can review our privacy policy here.

Cruises from San Diego

14 Matched Sailings

Departing	Itinerary and Ship	Length	Save to Favorites	Priced from
Oct 02, 2026 (Friday) Other Dates	16 Night Panama Canal Cruise Nieuw Amsterdam Holland America Line Starts: San Diego, California Ends: Fort Lauderdale, Florida Ports of Call: San Diego, Puerto Vallarta, Huatulco, Puerto Chiapas, Puerto Quetzal, Acajutla... (see itinerary) Special Promotions Have It All: Shore Ex Credit, Drinks, Dining & More Military Offer: $100 Onboard Credit Up to 40% OFF + Up to $400 Onboard Credit	16 Nights	Add to Favorites Compare Favorites	from $1,749 per person (double occupancy) Includes taxes & fees Learn More
Oct 03, 2026 (Saturday) Other Dates	14 Night Grand Voyage Cruise MSC Poesia MSC Cruises Starts: San Diego, California Ends: Miami, Florida Ports of Call: San Diego, Cabo San Lucas, Puntarenas, Cruising the Panama Canal, Colon, Cartagena, Miami (see itinerary) Special Promotions Up to 35% Off + Onboard Credit + Kids Sail Free	14 Nights	Add to Favorites Compare Favorites	from $1,198 per person (double occupancy) Includes taxes & fees Learn More
Oct 08, 2026 (Thursday) Other Dates	16 Night Panama Canal Cruise Eurodam Holland America Line Starts: San Diego, California Ends: Fort Lauderdale, Florida Ports of Call: San Diego, Cabo San Lucas, Acapulco, Huatulco, Puerto Chiapas, Puerto Quetzal, Puerto Caldera... (see itinerary) Special Promotions Have It All: Shore Ex Credit, Drinks, Dining & More Military Offer: $100 Onboard Credit Up to 40% OFF + Up to $400 Onboard Credit	16 Nights	Add to Favorites Compare Favorites	from $2,139 per person (double occupancy) Includes taxes & fees Learn More
Nov 06, 2026 (Friday) Other Dates	14 Night Eastbound Panama Canal Cruise Disney Magic Disney Cruises Starts: San Diego, California Ends: Galveston, Texas Ports of Call: San Diego, Cabo San Lucas, Puerto Vallarta, Cruising the Panama Canal, Cartagena, Georgetown ... (see itinerary)	14 Nights	Add to Favorites Compare Favorites	from $2,477 per person (double occupancy) Includes taxes & fees Learn More
Dec 19, 2026 (Saturday) Other Dates	15 Night Panama Canal Holiday Cruise Zaandam Holland America Line Starts: San Diego, California Ends: Fort Lauderdale, Florida Ports of Call: San Diego, Cabo San Lucas, Puerto Vallarta, Huatulco, Puerto Quetzal, Puerto Caldera... (see itinerary) Special Promotions Have It All: Shore Ex Credit, Drinks, Dining & More Military Offer: $100 Onboard Credit Up to 40% OFF + Up to $400 Onboard Credit $75 Onboard Credit	15 Nights	Add to Favorites Compare Favorites	from $1,799 per person (double occupancy) Includes taxes & fees Learn More
Jan 29, 2027 (Friday) Other Dates	16 Night Panama Canal Ocean to Ocean Cruise Island Princess Princess Cruises Starts: San Diego, California Ends: Fort Lauderdale, Florida Ports of Call: San Diego, Puerto Vallarta, Huatulco, Puerto Chiapas, Puntarenas, Fuerte Amador... (see itinerary) Special Promotions Princess Premier: Inclusive Cruise Package Princess Plus: Drinks, Tips & WiFi Up to 40% Off + $99 Deposit Up to $300 Instant Savings $60 Onboard Credit	16 Nights	Add to Favorites Compare Favorites	from $2,239 per person (double occupancy) Includes taxes & fees Learn More
Jan 30, 2027 (Saturday) Other Dates	15 Night Panama Canal Cruise Zuiderdam Holland America Line Starts: San Diego, California Ends: Miami, Florida Ports of Call: San Diego, Puerto Vallarta, Huatulco, Puerto Chiapas, Puerto Quetzal, Fuerte Amador... (see itinerary) Special Promotions Have It All: Shore Ex Credit, Drinks, Dining & More Military Offer: $100 Onboard Credit Up to 40% OFF + Up to $400 Onboard Credit $75 Onboard Credit	15 Nights	Add to Favorites Compare Favorites	from $1,749 per person (double occupancy) Includes taxes & fees Learn More
Feb 13, 2027 (Saturday) Other Dates	16 Night Panama Canal Cruise Norwegian Star Norwegian Cruise Line Starts: San Diego, California Ends: Miami, Florida Ports of Call: San Diego, Cabo San Lucas, Acapulco, Puerto Quetzal, Puntarenas, Panama City... (see itinerary) Special Promotions Free at Sea: Drinks, WiFi & More Free at Sea PLUS BOGO Airfare	16 Nights	Add to Favorites Compare Favorites	from $1,939 per person (double occupancy) Includes taxes & fees Learn More
May 24, 2027 (Monday) Other Dates	17 Night Panama Canal and Latin America Mexico Costa Rica and Colombia Cruise Azamara Quest Azamara Cruises Starts: San Diego, California Ends: Miami, Florida Ports of Call: San Diego, Cabo San Lucas, Acapulco, Puerto Quetzal, Acajutla, Puntarenas... (see itinerary) Special Promotions Up to $400 Credit on Back-to-Back Sailings Up to $1,000 Onboard Credit The Signature Collection - Exclusive Amenities	17 Nights	Add to Favorites Compare Favorites	from $6,609 per person (double occupancy) Includes taxes & fees Learn More
May 24, 2027 (Monday) Other Dates	35 Night San Diego to London Grand Voyage Cruise Azamara Quest Azamara Cruises Starts: San Diego, California Ends: Tilbury, United Kingdom Ports of Call: San Diego, Cabo San Lucas, Acapulco, Puerto Quetzal, Acajutla, Puntarenas... (see itinerary) Special Promotions Up to $400 Credit on Back-to-Back Sailings	35 Nights	Add to Favorites Compare Favorites	from $11,169 per person (double occupancy) Includes taxes & fees Learn More
Aug 09, 2027 (Monday) Other Dates	25 Night San Diego to New York City Cruise Crystal Serenity Crystal Cruises Starts: San Diego, California Ends: New York, New York Ports of Call: San Diego, Puerto Vallarta, Manzanillo, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas... (see itinerary) Special Promotions New-to-Crystal Guest Offer Save Up to $5,000 + $500 Onboard Credit	25 Nights	Add to Favorites Compare Favorites	from $10,400 per person (double occupancy) Includes taxes & fees Learn More
Oct 07, 2027 (Thursday) Other Dates	15 Night Panama Canal Eastward Cruise Serenade of the Seas Royal Caribbean Cruises Starts: San Diego, California Ends: Tampa, Florida Ports of Call: San Diego, Puerto Vallarta, Puerto Quetzal, Puntarenas, Cruising the Panama Canal, Cartagena... (see itinerary) Special Promotions Early Booking: $50 Onboard Credit Buy One, Get One 60% Off Kids Sail Free! The Signature Collection - Exclusive Amenities	15 Nights	Add to Favorites Compare Favorites	from $2,111 per person (double occupancy) Includes taxes & fees Learn More
Oct 07, 2027 (Thursday) Other Dates	16 Night Panama Canal Cruise Eurodam Holland America Line Starts: San Diego, California Ends: Fort Lauderdale, Florida Ports of Call: San Diego, Cabo San Lucas, Acapulco, Huatulco, Puerto Chiapas, Puerto Quetzal, Puerto Caldera... (see itinerary) Special Promotions Have It All: Shore Ex Credit, Drinks, Dining & More Military Offer: $100 Onboard Credit Up To 60% OFF	16 Nights	Add to Favorites Compare Favorites	from $2,769 per person (double occupancy) Includes taxes & fees Learn More
Dec 18, 2027 (Saturday) Other Dates	15 Night Panama Canal Holiday Cruise Zaandam Holland America Line Starts: San Diego, California Ends: Miami, Florida Ports of Call: San Diego, Cabo San Lucas, Puerto Vallarta, Manzanillo, Huatulco, Puerto Caldera... (see itinerary) Special Promotions Have It All: Shore Ex Credit, Drinks, Dining & More Military Offer: $100 Onboard Credit Up To 60% OFF	15 Nights	Add to Favorites Compare Favorites	from $2,604 per person (double occupancy) Includes taxes & fees Learn More